Revisiting a Classic Approach to theAspidospermaAlkaloids: An Intramolecular Schmidt Reaction Mediated Synthesis of (+)-Aspidospermidine
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چکیده
منابع مشابه
Synthesis of crispine A analogues via an intramolecular Schmidt reaction
An intramolecular Schmidt reaction strategy for the synthesis of various derivatives of crispine A using azido-ketone as a key intermediate is described.
متن کاملGold(I)-catalyzed intramolecular acetylenic Schmidt reaction.
Substituted pyrroles were prepared by a gold(I)-catalyzed acetylenic Schmidt reaction of homopropargyl azides. The reaction allows for regiospecific substitution at each position of the pyrrole ring under mild conditions. A mechanism in which azides serve as nucleophiles toward gold(I)-activated alkynes with subsequent gold(I)-aided expulsion of dinitrogen is proposed.
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An Efficient One-pot Synthesis of Dialkyl fumarates Mediated by inyltriphenylphosphonium Salt in the Intramolecular Wittig Reaction
An efficient three-component reaction of dialkyl acetylendicarboxylates and 2-Pyrrolidin in the presence of triphenylphosphine produces dialkyl 2-(2-Pyrrolidin-N-yl)-3-(triphenylphosphanylidene)succinate. These phosphoranes undergo mild intramolecular Wittig reaction to produce dialkyl (E)-2-(4,5-dihydro-3H-pyrrol-2-yl)fumarate in excellent yields.
متن کاملan efficient one-pot synthesis of dialkyl fumarates mediated by inyltriphenylphosphonium salt in the intramolecular wittig reaction
an efficient three-component reaction of dialkyl acetylendicarboxylates and 2-pyrrolidin in the presence of triphenylphosphine produces dialkyl 2-(2-pyrrolidin-n-yl)-3-(triphenylphosphanylidene)succinate. these phosphoranes undergo mild intramolecular wittig reaction to produce dialkyl (e)-2-(4,5-dihydro-3h-pyrrol-2-yl)fumarate in excellent yields.
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2005
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo051212n